Name | 1-(2,3-Dimethylphenyl)ethyl chloride |
Synonyms | Medetomidine Impurity 30 3-Dimethylphenyl)ethyl chloride 1-(1-CHLOROETHYL)-2,3-DIMETHYLPHENYL 1-(2,3-Dimethylphenyl)ethyl chloride 1-(2,3-dimethylphenyl)ethyl chloride 1-(1-Chloroethyl)-2,3-dimethylbenzene 1-(1-chloroethyl)-2,3-dimethylbenzene Benzene,1-(1-chloroethyl)-2,3-dimethyl- 1-(1-chlorethyl)-2,3-dimethylbenzylidene |
CAS | 60907-88-2 |
EINECS | 1308068-626-2 |
InChI | InChI=1/C10H13Cl/c1-7-5-4-6-10(8(7)2)9(3)11/h4-6,9H,1-3H3 |
Molecular Formula | C10H13Cl |
Molar Mass | 168.66 |
Density | 1.010 |
Boling Point | 233°C |
Flash Point | 93°C |
Vapor Presure | 0.0887mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.514 |
Use | 1-(1-chloroethyl)-2, 3-dimethylbenzene is an organic material, it is a key intermediate for the preparation of dexmedetomidine hydrochloride. |
preparation | in a ML three-necked flask, add 0.5 ml of tetrahydrofuran (THF) and 12g of magnesium bar (mo1), heated to reflux, 2, 3-dimethylbromobenzene 92.5g(0.5 mo1) in THF solution was added dropwise, refluxed for 1H, cooled to room temperature, acetaldehyde 36ML (0.64mol)/THF100mL was added dropwise, reflux was continued for 1H, and THF was distilled off under reduced pressure. After cooling, an aqueous solution of NH4Cl (25g of NH4C1 80ml of water) and 300ml of ethyl acetate were slowly added. The layers were separated by standing, the organic phase was dried over anhydrous Na2S04, filtered, the solvent was evaporated, and then distilled under reduced pressure to collect a fraction of 115-118 °c/300Pa. Anhydrous zncl2200 G and concentrated HCl 300ml were added, and after sufficiently dissolving, 150g(1 mol) of the above fraction was added, followed by vigorous stirring for 4 hours. Layer, anhydrous CaC12 dry organic phase, filtered, filtrate distilled off solvent, vacuum distillation, collect 80~83 deg C/300Pa fraction to obtain product 1-(1-chloroethyl)-2, 3-dimethylbenzene (142g, yield 84.2%). |